✦ LIBER ✦
Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp
✍ Scribed by Jonathan A. Fletcher; Jack L. Pinkus; Janice M. Lage; Cynthia C. Morton; Geraldine S. Pinkus
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 378 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Previous cytogenetic analyses revealed t(6;20)(p21;q 13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q 13). Subsequent combined immunohistochernical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.