Clofibrate microcapsules II: Effect of wall thickness on release characteristics

✍ Scribed by P. L. Madan

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 416 KB
• Volume: 70
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600700422

✦ Synopsis

Eq. 1 employs urn. Table IV shows a strong intercorrelation between urn and up (arc co9 0.75 = 41') (20). Similarly, in Eq. 8, urn replaces a , of Eq. 4 in the treatment of electronic effects at position 6 (arc cos 0.84 = 33O). Another interesting fact derived from the correlation matrix is cohsiderable autocorrelation of r, especially at position 2, with am and a , . A similar phenomenon was observed for some benzene derivatives (21).

The pKa values of 33 disubstituted and trisubstituted purines were calculated from Eqs. 7 and 8 and compared with measured values reported in the literature (Table VI). The agreement between observed and predicted values is reasonable considering the variation in experimental methods.

Studies are in progress on the correlation of the antitumor potency and toxicity of polysubstituted purines with the structural parameters described in this paper.