“Clip” and “Click” Chemistries Combination: Toward Easy PEGylation of Degradable Aliphatic Polyesters

✍ Scribed by Hélène Freichels; Vincent Pourcelle; Cécile S. Le Duff; Jacqueline Marchand-Brynaert; Christine Jérôme

• Book ID: 102496750
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 295 KB
• Volume: 32
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.201000803

✦ Synopsis

Abstract

α‐Methoxy‐ω‐alkyne poly(ethylene glycol) (PEG) was tagged with pendent N‐hydroxy‐succinimidyl activated esters by photografting of a molecular clip. This easily synthesized heterofunctional PEG was found to be a versatile building block for (i) conjugation with an amino derivative and (ii) grafting to azido functional aliphatic polyesters backbone by Huisgen's 1,3‐dipolar cycloaddition. This original combination of “clip” and “click” reactions provides a versatile and straightforward pathway for the synthesis of functional amphiphilic and degradable copolymers valuable for biomedical applications such as in drug‐delivery. magnified image