Clinicopathological studies and operative results of hepatocellular carcinoma with liver cirrhosis, comparing HB-associated cirrhosis to alcoholic and post-transfusion cirrhosis

Alterations of RB1, p53 and Wnt pathways

Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis

✍ Yoshihiro Edamoto; Akira Hara; Wojciech Biernat; Luigi Terracciano; Gieri Cathom 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 259 KB 👁 1 views

## Abstract Major etiologic factors associated with human hepatocellular carcinomas (HCCs) include infection with hepatitis C (HCV) and hepatitis B virus (HBV), excess alcohol intake and aflatoxin B~1~ exposure. While the G→T __p53__ mutation at codon 249 has been identified as a genetic hallmark o