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Clinicopathological and prognostic significance of HIF-1α and HIF-2α expression in small cell lung cancer

✍ Scribed by Luan, Yajing; Gao, Cuicui; Miao, Yajing; Li, Yanlei; Wang, Zhengyan; Qiu, Xiaofei

Book ID
122932713
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
957 KB
Volume
209
Category
Article
ISSN
0344-0338

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## Abstract Hypoxia‐inducible factor (HIF)‐1 and HIF‐2 are heterodimeric transcription factors that mediate the cellular response to hypoxia. Their key regulatory subunits, HIF‐1α and HIF‐2α, are induced similarly by hypoxia, but their functional roles in cancer may be distinct and isoform‐specific