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Clinicopathologic significance of DNA mismatch repair defects in endometrial cancer: The devil is in the details

โœ Scribed by Paul J. Goodfellow


Book ID
113962004
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
96 KB
Volume
113
Category
Article
ISSN
0090-8258

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Model-based prediction of defective DNA
โœ Frank Sinicrope; Nathan R. Foster; Daniel J. Sargent; Stephen N. Thibodeau; Thom ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 149 KB

## Abstract ## BACKGROUND: Colon cancers with defective DNA mismatch repair (MMR) have a favorable prognosis and may lack benefit from 5โ€fluorouracilโ€“based adjuvant chemotherapy. The authors developed models to predict MMR deficiency in sporadic colon cancer patients using routine clinical and pat