✦ LIBER ✦

Clinicopathologic significance of CD105 expression in squamous cell carcinoma of the hypopharynx

✍ Scribed by Chih-Yen Chien; Chih-Ying Su; Chung-Feng Hwang; Hui-Ching Chuang; Yea-Chyang Hsiao; Shu-Ling Wu; Chao-Cheng Huang

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 308 KB
Volume: 28
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20364

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

Induction of angiogenesis is a key process in tumor growth and metastasis. We studied the CD105 (endoglin) and vascular endothelial growth factor (VEGF) in hypopharyngeal cancer to evaluate their clinicopathologic significance.

Methods.

Seventy‐three patients who underwent complete excision of hypopharyngeal cancer were included in this study. Clinicopathologic data were collected retrospectively. Immunohistochemical analysis was performed with antibodies of CD105 and VEGF. Positive‐stained microvessels for CD105 were counted on hot spots of tumors. The staining intensity for VEGF was also evaluated.

Results.

High expression of CD105 correlated significantly with positive nodal metastasis (p < .001) and TNM stage (p < .01). High expression of VEGF correlated significantly with advanced tumor (T) classification (p < .01). The overall 5‐year survival rate was worse in patients with higher CD105 expression (p < .001), advanced TNM stage (p < .01), advanced T classification (p < .01), and positive nodal metastasis (p < .001). Furthermore, Cox regression analysis revealed that CD105 expression in microvessels of tumor tissue, advanced T classification, and nodal status were independent factors for survival.

Conclusion.

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