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Clinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast

โœ Scribed by Jorge S. Reis-Filho; Joana Cancela Paredes; Fernanda Milanezi; Fernando C. Schmitt


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
44 KB
Volume
94
Category
Article
ISSN
0008-543X

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## Loss of expression of the intercellular adhesion molecule E-cadherin frequently occurs in invasive lobular breast carcinomas as a result of mutational inactivation. Expression patterns of E-cadherin and the molecules comprising the cytoplasmic complex of adherens junctions, -, -and -catenin, we

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The cell-cell adhesion receptor gene E-cadherin (CDH1) is expressed by epithelial cells, in which it mediates adhesion and morphogenesis. Invasive lobular carcinoma (ILC) characteristically infiltrates diffusely as single cells; by immunohistochemistry, many of these tumours lack E-cadherin expressi