Clinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast
โ Scribed by Jorge S. Reis-Filho; Joana Cancela Paredes; Fernanda Milanezi; Fernando C. Schmitt
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 44 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0008-543X
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Lobular carcinoma in situ (LCIS) of the breast is commonly identified as an incidental finding in breast biopsies performed because of either a mammographic abnormality or a palpable mass. Although long recognized as an entity, the significance and optimal treatment of LCIS remains controversial. In
## Loss of expression of the intercellular adhesion molecule E-cadherin frequently occurs in invasive lobular breast carcinomas as a result of mutational inactivation. Expression patterns of E-cadherin and the molecules comprising the cytoplasmic complex of adherens junctions, -, -and -catenin, we
The cell-cell adhesion receptor gene E-cadherin (CDH1) is expressed by epithelial cells, in which it mediates adhesion and morphogenesis. Invasive lobular carcinoma (ILC) characteristically infiltrates diffusely as single cells; by immunohistochemistry, many of these tumours lack E-cadherin expressi