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Clinicopathologic correlates of loss of heterozygosity in Wilms' tumor: A preliminary analysis

✍ Scribed by Grundy, Paul; Telzerow, Perry; Moksness, Jami; Breslow, Norman

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 519 KB
Volume: 27
Category: Article
ISSN: 0098-1532
DOI: 10.1002/(sici)1096-911x(199611)27:5<429::aid-mpo7>3.0.co;2-o

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✦ Synopsis

I

Wilms' tumor-specific loss of heterozygosity (LOH) for DNA markers located at chromosomes llp13, llp15, 16q, and l p has been reportedtooccur in a minorityofWiIms'tumors. We hypothesized that tumors classified by region of LOH would exhibit specific clinicopathologic patterns. We have therefore determined the constitutional and tumor genotypes for markers at llp13, llp15, 16q, and l p in a large series of Wilms' tumor patients who were registered on a Pediatric Oncology Group study and on the National Wilms' Tumor Study, to determine whether tumor-specific LOH for any of these regions was associated with any specific phenotype.

Of 286 cases, 27% had LOH at both 11 p l 3 and p15 (BOTH), 3% at 1 lp13 only, 8% at 11 p l 5 only, and 62% at neither. Significant associations were found between younger age at diagnosis and LOH for BOTH, but not for 11 p l 5 only, and between the presence of intralobar nephrogenic rests and LOH for BOTH. The incidence of nephrogenic rests (all types combined) and of bilateral tumors was the same in tumors with or without LOH. There was a negative association between anaplastic histology and LOH for 11 p. There was no association between LOH on 11 p and outcome as assessed by relapsefree and overall survival.

The associations between age at diagnosis and LOH are interpreted as suggesting the exis-tenceofaWiIms'tumor locuson 1 lpinaddition to WTl at 11 p l 3 and the putative WJ2 at 11 pl5. LOH for chromosome 16q was identified in 17% of 204 tumors and was associated with a significantly worse outcome. Outcome for patients with LOH for 1 p was also worse but not significantly SO.

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