Clinicopathologic characteristics of adenosquamous carcinoma of the lung

✍ Scribed by Shinzo Takamori; Yukio Shimosato; Masayuki Noguchi; Teruo Kakegawa; Shojiroh Morinaga; Tomoyuki Goya; Shoichiro Tsugane

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 735 KB
• Volume: 67
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19910201)67:3<649::aid-cncr2820670321>3.0.co;2-b

✦ Synopsis

Fifty-six cases of surgically resected adenosquamous carcinoma of the lung were studied clinicopathologically, and their outcome was compared with that of adenocarcinomas and squamous cell carcinomas of the lung. The frequency rate of adenosquamous carcinoma was 2.6% of 2160 primary lung cancers resected in the National Cancer Center Hospital (Tokyo, Japan). The survival curves of patients with adenosquamous carcinomas, adenocarcinomas, and squamous cell carcinomas indicated that the outcome of adenosquamous carcinoma was poorer than that of adenocarcinomas and squamous cell carcinomas, particularly in Stages I and 11. The amount of adenocarcinoma component did not affect the survival rate, although the histologic features of metastatic lymph nodes was somewhat influenced by the histologic type of the primary tumors. The histologic subtype of adenosquamous carcinoma was one of the independent prognostic determinants. Cancer 67:649-654,1991.

HE DEnNITlON OF adenosquamous carcinoma of the

T lung has been poorly described. The incidence of adenosquamous carcinoma varied from 0.4% to 4.0% in previously published reports.'-' Fitzgibbons and Kern reviewed 2 1 lung carcinomas which were initially diagnosed as adenosquamous carcinomas (2.0%) among 1125 primary lung cancers and found seven cases (0.6%) which could be correctly diagnosed as adenosquamous carcinoma because of the presence of unequivocal squamous and glandular differentiation.' The histologic classification of the World Health Organization (WHO) indicated simply that adenosquamous carcinoma is composed of both squamous cell carcinomatous and adenocarcinomatous components,' and these criteria were not sufficiently de-