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Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors

✍ Scribed by Shingo Senba; Fumio Konishi; Tomomi Okamoto; Hiroshi Kashiwagi; Kyotaro Kanazawa; Michiko Miyaki; Motoko Konishi; Toshihiko Tsukamoto

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 189 KB
Volume: 82
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19980115)82:2<279::aid-cncr6>3.0.co;2-m

No coin nor oath required. For personal study only.

✦ Synopsis

METHODS.

Fresh or frozen samples of 103 nonfamilial colorectal carcinomas were Tochigi, Japan.

examined for RERs using the polymerase chain reaction (PCR) and specific micro-2 Department of Biochemistry, Tokyo Metropolisatellite primers. The authors also identified mutations of the hMSH2 and hMLH1 tan Institute of Medical Science, Tokyo, Japan.

genes in RER positive samples by a PCR single strand conformational polymorphism analysis followed by direct nucleotide sequencing.

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