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Clinical value of the guanase screening test in donor blood for prevention of posttransfusional non-A, non-B hepatitis

✍ Scribed by Susumu Ito; Yasuhiro Tsuji; Naoyuki Kitagawa; Ishihara Akihiko; Jyoji Syundo; Yoshiyuki Tamura; Seiichiro Kishi; Hiroyoshi Mori

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
255 KB
Volume
8
Category
Article
ISSN
0270-9139

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✦ Synopsis

We adopted an automated method for measuring guanase in donor blood and examined the incidence of posttransfusional non-A, non-B hepatitis when donor blood with high guanase activities was excluded. Sixtyseven (2.4%) of 2,826 units were excluded from use in transfusion because they had guanase activities above 1.71 units per liter. Of 112 recipients, 8 (7%) developed posttransfusional non-A, non-B hepatitis. The incidence of posttransfusional non-A, non-B hepatitis was 17% before adoption of the guanase screening test and 7% after its adoption. Thus, the incidence of posttransfusional non-A, non-B hepatitis was significantly decreased after adoption of this screening test.

This study shows that, for prevention of posttransfusional non-A, non-B hepatitis, it is important to screen donor blood for guanase activity and discard blood with high activities.

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