Clinical value of preoperative cancer chemotherapy as an index to the changes in tissue catalase activity
✍ Scribed by Shigeru Fujimoto
- Publisher
- John Wiley and Sons
- Year
- 1966
- Tongue
- English
- Weight
- 364 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
The effect of preoperative cancer chemotherapy on tissue catalase levels in 25 patients with gastric cancer has been studied. In the non-neoplastic diseases studied elevated tissue catalase levels are shown. Preoperative cancer chemotherapy resulted in a significant inuease in liver and metastatic lyniph node catalase levels. There was a marked lowering of the hepatic catalase leveI in patients with either unresectable stomach cancer or liver metastasis. Preoperative cancer chemotherapy has not made it necessary to postpone operation because of its side effects.
NZYME CHEMISlKY HAS ATTRACTED CONSIDER-
E able clinical interest recently because
changes in blood and tissue are characteristic in various diseases; thus, enzyme chemistry is valuable in clinical application for supplementary diagnosis, evaluation of therapeutic effect and judgment of prognosis. Enzymology also may be useful in malignant disease. It is well known that the liver catalase activity decreases, especially in the organisms bearing the malignant tumor. Greensteinlo has summarized the experimental work recently and has demonstrated that the peroxide-splitting enzyme, ca talase, apparently is reduced considerably in the liver of a rat with tumor; its depression is progressive with and proportional to the growth of the tumor.
Few experiments have been repoi ted of the liver catalase activity in the human. Blumenthal,z Brahn,3 Hishikawalz and Ma-son16 are among the workers in clinical liver catalase activity.
This paper deals with the cIinical appraisal of the preoperative administration of antitumor agents and the resultant changes in the tissue ca talnse level.
MATERIALS
In the department of surgery of Chiba University, Japan, preoperative cancer chemo-From the