Clinical utility of apparent diffusion coefficient (ADC) values in patients with prostate cancer: Can ADC values contribute to assess the aggressiveness of prostate cancer?
✍ Scribed by Yasushi Itou; Katsuyuki Nakanishi; Yoshifumi Narumi; Yasuko Nishizawa; Hideaki Tsukuma
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 427 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To retrospectively evaluate the relationship between apparent diffusion coefficient (ADC) values and Gleason score (GS) in prostate cancer.
Methods
A total of 60 patients who underwent radical prostatectomy for clinically localized prostate cancer were selected for this study. Diffusion‐weighted magnetic resonance (MR) images were obtained using a 1.5 T system. ADC values were analyzed between three groups: GS of 6 or less (n = 7); GS of 7 (n = 37); and GS of 8 or higher (n = 16). ADC values of the three GS groups were statistically analyzed in order to determine the relationship with GS. In the 37 patients with GS = 7 the difference in ADC values between GS 3+4 and GS 4+3 was analyzed.
Results
Median ADC values (10^−3^ mm^2^/s) of the three GS groups were 1.04 (GS = 6 or less), 0.867 (GS = 7), and 0.729 (GS = 8 or higher). Although there was considerable overlap among the groups, the differences in ADC were statistically significant (P < 0.0001). There was a significant inverse correlation between GS and ADC values (z = −0.437, P < 0.0005). Median ADC values (10^−3^ mm^2^/s) of GS 3+4 and GS 4+3 patients were 0.88 and 0.814, respectively (P < 0.05).
Conclusion
ADC values showed a negative correlation with GS. Pathologically, however, there was considerable intrasubject heterogeneity. J. Magn. Reson. Imaging 2011;33:167–172. © 2010 Wiley‐Liss, Inc.