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Clinical usefulness of111In-oxine-labeled autologous lymphocytes in kidney-graft rejection

✍ Scribed by Jose Martin-Comin; Manuel Roca; Jose M. Griñó; Carmen Paradell; Antonio Caralps

Book ID
104682375
Publisher
Springer
Year
1985
Tongue
English
Weight
484 KB
Volume
10
Category
Article
ISSN
0340-6997

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✦ Synopsis

A method of lymphocyte labeling with 111In-oxine was applied for the diagnosis of acute kidney-graft rejection. After the injection of labeled lymphocytes, scintigrams of the graft area, contralateral iliac fossa, and spleen were obtained. Indexes of activity were calculated. No patient without rejection (n = 3) showed lymphocyte graft deposition. Twenty-two patients with acute graft rejection and two patients with on abdominal-wall abscess over the graft area showed lymphocyte graft trapping. When acute graft rejection was present, index i (graft/contralateral iliac fossa) increased, and index c (spleen/graft) decreased. The improvement after the rejection crisis occurred parallel to the decrease in index i. Index c remained unchange regardless of rejection evolution. In summary, 111In-oxine-labeled lymphocytes may be used for the diagnosis of acute kidney-graft rejection and for evolving control.

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