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Clinical Use of Anti-CD25 Antibody Daclizumab to Enhance Immune Responses to Tumor Antigen Vaccination by Targeting Regulatory T cells

โœ Scribed by Andrew J. Rech; Robert H. Vonderheide


Book ID
111399339
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
177 KB
Volume
1174
Category
Article
ISSN
0890-6564

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## Abstract CD4^+^CD25^+^ natural T regulatory cells (Tregs) have been shown to suppress protective immune responses in several different vaccination models. Since the effect of Tregs on vaccination against tuberculosis (Tb) was unknown, we used a murine model to investigate whether natural Tregs s