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Clinical use and pharmacological properties of selective COX-2 inhibitors

✍ Scribed by Shaojun Shi; Ulrich Klotz


Publisher
Springer
Year
2007
Tongue
English
Weight
429 KB
Volume
64
Category
Article
ISSN
0031-6970

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DuP697, 2-bromo-4-(4'-sulfonylmethyl)phenyt-5-(4'-fluoro)phenylthiophene, is a selective type 2 cyclooxygenase (COX-2) inhibitor. Its relatively weak COX-2 selectivity coupled with a poor human pharmacokinetic profile led us to seek improvements on the in vitro selectivity while at the same time, ad