Clinical targeting of the TNF and TNFR superfamilies
β Scribed by Croft, Michael; Benedict, Chris A.; Ware, Carl F.
- Book ID
- 119972061
- Publisher
- Nature Publishing Group
- Year
- 2013
- Tongue
- English
- Weight
- 702 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1474-1776
- DOI
- 10.1038/nrd3930
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π SIMILAR VOLUMES
Tumor necrosis factor (TNF) superfamily is a rapidly growing family of cytokines that interacts with a corresponding superfamily of receptors. Liga- receptor interactions of this superfamily are involved in numerous biological processes ranging from hematopoiesis to pleiotropic cellular responses, i
## Abstract TNF is a pleiotropic cytokine with intriguing biphasic proβinflammatory and antiβinflammatory effects. Our previous studies demonstrated that TNF upβregulated FoxP3 expression and activated and expanded CD4^+^FoxP3^+^ regulatory T cells (Tregs) via TNFR2. Furthermore, TNFR2βexpressing T