Clinical studies of the effect of (+) and (−)-oxaprotiline upon noradrenaline uptake

✍ Scribed by S. A. Checkley; C. Thompson; S. Burton; C. Franey; J. Arendt

• Publisher: Springer
• Year: 1985
• Tongue: English
• Weight: 380 KB
• Volume: 87
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00431790

✦ Synopsis

In six normal male subjects the mydriatic effect of tyramine eye drops was inhibited by 1 day's treatment with desipramine and the (+)-but not the (-)-enantiomer of oxaprotiline. In the same experiment, the secretion of melatonin was increased after treatment with (+)-but not with (-)-oxaprotiline. The effects of (+)-oxaprotiline and of desipramine treatment were similar, as were those of (-)-oxaprotiline and placebo.

These findings extend to clinical studies the demonstration in animal experiments of stereo-specificity for the effects of (+)-and (-)-oxaprotiline upon noradrenaline uptake. A comparison of the effects of the two enantiomers should provide an ideal strategy for studying effects of noradrenaline uptake blockade in clinical studies.