𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Clinical studies of seven patients with rheumatoid arthritis and uniquely large amounts of rheumatoid factor

✍ Scribed by E. C. Franklin; H. G. Kunkel; J. R. Ward

Publisher
John Wiley and Sons
Year
1958
Tongue
English
Weight
661 KB
Volume
1
Category
Article
ISSN
0004-3591

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## Abstract Hidden 19S IgM rheumatoid factors (RF)β€”i.e., RF detected in the IgM‐containing fraction after separation of the serum at an acid pHβ€”have been found in 68% of patients with seronegative juvenile rheumatoid arthritis (JRA). Inhibition studies utilizing a hemolytic assay for RF were perfor

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Objective. To compare the B cell repertoire of normal individuals and patients with rheumatoid arthritis (RA) and, specifically, to identify precursor B cells with the potential to secrete rheumatoid factor (RF) and to understand the T helper cell requirements for the production of this autoantibody