𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Clinical significance of drug-resistant viruses

✍ Scribed by Huraux, J.-M.

Book ID
122038632
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
68 KB
Volume
143
Category
Article
ISSN
0923-2516

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## Abstract Herpes simplex virus (HSV) resistance to acyclovir or foscarnet results from mutations in viral thymidine kinase (TK) and/or DNA polymerase (pol) genes. Replication kinetics and virulence of TK and/or DNA pol clinical mutants were assessed using models of mouse encephalitis and cotton r