Clinical relevance of the quantification of apolipoprotein E in cerebrospinal fluid
✍ Scribed by Jörg Carlsson; Victor W. Armstrong; Hansotto Reiber; Klaus Felgenhauer; Dietrich Seidel
- Book ID
- 115827082
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 698 KB
- Volume
- 196
- Category
- Article
- ISSN
- 0009-8981
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📜 SIMILAR VOLUMES
## Abstract We developed a simple method to detect apolipoprotein E (Apo E) polymorphism distribution in approximately 20 μL of unconcentrated cerebrospinal fluid (CSF). A combination of isoelectric focusing in 3 M urea gel and immunoblotting was employed. Apo E phenotypes were identified in CSF sa
Sixteen out of eighteen meningeal carcinomas (89%) secreted carcinoembryonic antigen (CEA) into the cerebrospinal fluid, where it could be quantified separately from the portion originating from the circulating blood. The discrimination of both fractions was performed according to an empirical appro