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Clinical relevance of Neutral Endopeptidase (NEP/CD10) in melanoma

✍ Scribed by Elsa F Velazquez; Molly Yancovitz; Anna Pavlick; Russell Berman; Richard Shapiro; Dusan Bogunovic; David O'Neill; Yi-Lo Yu; Joanna Spira; Paul J Christos; Xi Kathy Zhou; Madhu Mazumdar; David M Nanus; Leonard Liebes; Nina Bhardwaj; David Polsky; Iman Osman

Book ID
119905440
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
944 KB
Volume
5
Category
Article
ISSN
1479-5876

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## Abstract Neutral endopeptidase (NEP/CD10) is a cell surface zinc metalloprotease cleaving peptide bounds on the amino terminus of hydrophobic amino acids and inactivating multiple physiologically active peptides. Loss or decrease in NEP/CD10 expression have been reported in many types of maligna