Clinical relevance of maspin expression in bladder cancer
β Scribed by Wolf-D. Beecken; Tobias Engl; Knut Engels; Christa Blumenberg; Elsie Oppermann; Kevin Camphausen; Yuen Shing; Gerd Reinecke; Dietger Jonas; Roman Blaheta
- Book ID
- 106033042
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 354 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0724-4983
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Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most
## Abstract The tumor suppressor gene __maspin__ has been reported to inhibit the invasiveness and motility of breast cancer cells. It has been reported that maspin is expressed in normal human mammary epithelial cells but is downregulated during cancer progression, and that p53 could induce maspin