✦ LIBER ✦

Clinical recurrence of hepatitis A following liver transplantation for acute liver failure

✍ Scribed by Edward Gane; Richard Sallie; Mohammed Saleh; Bernard Portmann; Prof. Roger Williams

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 650 KB
Volume: 45
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890450107

No coin nor oath required. For personal study only.

✦ Synopsis

This paper documents clinically significant recurrence of hepatitis A virus (HAV) infection in a 63-year-old man transplanted for HAV-related acute liver failure. HAV RNA was documented in the explant and, following early clearance from the blood and graft, was again detected in postoperative biopsies at the time of an acute hepatic illness. Although the clinical and biochemical abnormalities resolved completely, the patient had a second episode of graft dysfunction 6 months later and investigations revealed hepatitis C virus (HCV)-related chronic active hepatitis consistent with acquired HCV infection at the time of transplantation. The possible interaction with hepatitis A may have delayed the appearance of hepatitis C. Administration of HAV immunoglobulin at the time of transplantation should be considered in all cases of HAV-related fulminant hepatic failure.

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