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Clinical potential of the mTOR targets S6K1 and S6K2 in breast cancer

✍ Scribed by Gizeh Pérez-Tenorio; Elin Karlsson; Marie Ahnström Waltersson; Birgit Olsson; Birgitta Holmlund; Bo Nordenskjöld; Tommy Fornander; Lambert Skoog; Olle Stål

Book ID
106378895
Publisher
Springer US
Year
2010
Tongue
English
Weight
473 KB
Volume
128
Category
Article
ISSN
0167-6806

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✍ Elin Karlsson; Marie Ahnström Waltersson; Josefine Bostner; Gizeh Pérez-Tenorio; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 604 KB

## Abstract The chromosomal region 11q13 is amplified in 15–20% of breast cancers; an event not only associated with estrogen receptor (ER) expression but also implicated in resistance to endocrine therapy. Coamplifications of the 11q13 and 8p12 regions are common, suggesting synergy between the am