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Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias

✍ Scribed by Robin E. Norris; Peter C. Adamson

Book ID
105993265
Publisher
Springer
Year
2009
Tongue
English
Weight
270 KB
Volume
65
Category
Article
ISSN
0344-5704

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Methotrexate and asparaginase combinatio
Methotrexate and asparaginase combination chemotherapy in refractory acute lymphoblastic leukemia of childhood
✍ Jeffrey S. Lobel; Richard T. O'Brien; Sue McIntosh; Gregg T. Aspnes; Robert L. C πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 526 KB

Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3