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Clinical Pharmacology of Rasagiline: A Novel, Second-Generation Propargylamine for the Treatment of Parkinson Disease

โœ Scribed by Chen, Jack J.; Swope, David M.


Book ID
121305286
Publisher
Sage Publications
Year
2005
Tongue
English
Weight
214 KB
Volume
45
Category
Article
ISSN
0091-2700

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## Abstract A series of __O__โ€alkyl iminoxylitol derivatives was synthesized and evaluated as ฮฒโ€glucocerebrosidase (GCase) inhibitors. This structureโ€“activity study shows a dramatic influence of the position of the alkyl chain (ฮฑโ€C1, O2, O3, or O4) on human GCase inhibition. Remarkably, 1,2โ€shift o