Clinical pharmacology of exogenously administered alkaline phosphatase
โ Scribed by P. Pickkers; F. Snellen; P. Rogiers; J. Bakker; P. Jorens; J. Meulenbelt; H. Spapen; J. E. Tulleken; R. Lins; S. Ramael; M. Bulitta; J. G. van der Hoeven
- Book ID
- 105921811
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 216 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0031-6970
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## Abstract This paper is a study to identify the clinical significance of highโmolecularโmass alkaline phosphatase (ALP:E:C.3.1.3.1.), ALPโlipoproteinโX complex (LPโX) and intestinal variant ALP. We used cellulose acetate and agarose gels and techniques including wheat germ lectin, cetavlonโdiethy
Background: Increased activity of intestinal alkaline phosphatase (AP) occurs locally in patients with ulcerative colitis (UC), aimed at repairing inflammatory tissue damage. We evaluated the safety and preliminary efficacy of exogenous AP administered to patients with UC in an open-label, first-in-