Clinical pharmacology of an atrasentan and docetaxel regimen in men with hormone-refractory prostate cancer
โ Scribed by Younis, Islam R.; George, Daniel J.; McManus, Terence J.; Hurwitz, Herbert; Creel, Patricia; Armstrong, Andrew J.; Yu, Jing Jie; Bacon, Kristina; Hobbs, Gerald; Peer, Cody J.; Petros, William P.
- Book ID
- 125344284
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 299 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND. Prostate cancer is the second leading cause of cancer mortality among men in the U.S. To the authors' knowledge, there is no proven, effective, secondโline therapy for docetaxelโrefractory disease. Recent data suggest that platinum salts may be effective when combined wi
## Abstract ## BACKGROUND. The objective of this study was to evaluate the efficacy and safety of atrasentan (Xinlay), a selective endothelinโA receptor antagonist, in patients with metastatic hormoneโrefractory prostate cancer (HRPC). ## METHODS. This multinational, doubleโblind, placeboโcontro