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Clinical Laboratory Analysis of Immunoglobulin Heavy Chain Variable Region Genes for Chronic Lymphocytic Leukemia Prognosis

✍ Scribed by Szankasi, Philippe; Bahler, David W.


Book ID
125460905
Publisher
American Society for Investigative Pathology
Year
2010
Tongue
English
Weight
307 KB
Volume
12
Category
Article
ISSN
1525-1578

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The level of somatic point mutation in immunoglobulin genes is an important prognostic indicator for patients with chronic lymphocytic leukemia (CLL). Mutation analysis presently focuses solely upon the heavy chain IGHV gene, however mutation is a stochastic process that also targets IGHD and IGHJ g