Clinical investigation in Duchenne muscular dystrophy: Penicillamine and vitamin E

✍ Scribed by Dr. Gerald M. Fenichel; Dr. Michael H. Brooke; Dr. Robert C. Griggs; Dr. Jerry R. Mendell; Mr. J. Phillip Miller; Dr. Richard T. Moxley III; Dr. Jane H. Park; Mr. Michael A. Provine; Ms. Julaine Florence; Mr. Kenneth K. Kaiser; Ms. Wendy M. King; Ms. Shree Pandya; Ms. Jenny Robison; Ms. Linda Signore

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 359 KB
• Volume: 11
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/mus.880111110

✦ Synopsis

A double-blind controlled trial of penicillamine and vitamin E against placebo was conducted in 106 boys with Duchenne muscular dystrophy. Nine dropped out of the study after being randomized. Patients were evaluated using an established protocol that measures muscle strength, joint contractures, functional grade, and pulmonary function. The trial lasted for 18 months. The power of the study to detect a 75% slowing of the disease was 0.95 at a P less than 0.05. No therapeutic effect was observed in the patients taking penicillamine and vitamin E as compared with those taking placebo.