Clinical investigation in Duchenne Dystrophy: V. Use of creatine kinase and pyruvate kinase in carrier detection
โ Scribed by Dr. Robert C. Griggs; Dr. Jerry R. Mendell; Dr. Michael H. Brooke; Dr. Gerald M. Fenichel; Dr. J. Phillip Miller; Dr. Michael Province; Dr. Richard T. Moxley III; Ms. Donna Huntzinger; Dr. Arthur Vaughn; Ms. Melinda Cohen; Dr. P. Michael Conneally; Dr. Phillip Bach
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 615 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0148-639X
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๐ SIMILAR VOLUMES
## Abstract In the absence of an unambiguous test for identifying Duchenne muscular dystrophy (DMD) heterozygotes, methods are needed for combination of the results of individually equivocal tests as effectively and rationally as possible. We used logistic discrimination to assess the effectiveness
Carbonic anhydrase III (CAIII) and creatine kinase (CK) were measured in plasma samples from a series of females at-risk as carriers of Duchenne muscular dystrophy and compared with control groups. Both plasma CAIII and CK levels were raised in a proportion of carriers. Although measurement of CAIII