Clinical implications of the tumor necrosis factor family in benign and malignant hematologic disorders : A short review
✍ Scribed by Anas Younes; Bharat B. Aggarwall
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 190 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Tumor necrosis factor (TNF), originally identified as a factor produced in the serum of endotoxin‐injected animals, is a cytokine that mediates tumor necrosis. To date, 20 different members of the TNF superfamily and 21 different receptors have been identified. All ligands of the TNF superfamily have been found to activate transcription factor NF‐κB and c‐Jun kinase. Members of this family have diverse biologic effects, including induction of apoptosis, promotion of cell survival, and regulation of the immune system. The current review focuses on four members that play important roles in regulating hematopoietic cells and are involved in the pathogenesis of several hematologic malignancies. The potential therapeutic use of these members also is discussed. Cancer 2003;98:458–67. © 2003 American Cancer Society.
DOI 10.1002/cncr.11524