𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Clinical implications of p53 mutations

✍ Scribed by R. R. Wallace-Brodeur; S. W. Lowe

Book ID
105759830
Publisher
Springer
Year
1999
Tongue
English
Weight
162 KB
Volume
55
Category
Article
ISSN
1420-682X

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## Abstract The p53 tumor suppressor‐signaling pathway is inactivated in most human cancers. Depending on how p53 is targeted during tumorigenesis impacts whether partial or full tumor suppressor activity is lost. The degree of remaining p53 activity, if any, intuitively impacts the tumor phenotype