## Abstract Stiff person syndrome (SPS) is a rare, chronic disorder characterized by painful spasm and stiffness. We investigated the quality of life (QoL) in SPS patients, and identified factors associated with impairment in patients' QoL. Twentyโfour SPS patients (10 men, 14 women; mean age ยฑ S.D
Clinical hallmarks and epidemiology of stiff person syndrome in Tanzania
โ Scribed by Dekker, M.; Urasa, S.; Maro, V.; Kinabo, G.; Howlett, W.
- Book ID
- 122419338
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 64 KB
- Volume
- 333
- Category
- Article
- ISSN
- 0022-510X
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๐ SIMILAR VOLUMES
## Abstract We measured expression of central nervous system GABAโA receptors with ^11^Cโflumazenil (^11^CโFMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced ^11^CโFMZ binding potential (BP) in motorโpremotor cortex, and increased ^11^CโFMZ BP in the cerebellar nuclei.
We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff-person syndrome in an open-label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred