โ Scribed by Austin-Ward, Enrique Daniel; Castillo, Silvia; Dragnic, Yuri; Sanz, Patricia; Salazar, Samuel; Knoll, Joan H. M.
No coin nor oath required. For personal study only.
Marker chromosomes present a problem in genetic counseling because there are often no clear phenotype-karyotype correlations. We present the clinical findings in a patient who is mosaic for a supernumerary marker chromosome 20 determined by fluorescence in situ hybridization (FISH) and compare these findings to others reported in the literature.
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We read with interest the review article by Dr. Crolla [1998] which stated that supernumerary marker chromosomes from all the human autosomes except chromosome 5 have been reported. We therefore describe a patient with a supernumerary ring chromosome 5. The patient, a boy, was the only child of hea
## Trisomy 8 Mosaicism in a Patient With Tetraamelia To the Editor: Trisomy 8 is detected in 0.8% of spontaneous abortions . In neoplasias, especially in myeloid leukaemias, trisomy 8 is a frequent somatic aberration . In liveborn infants trisomy 8 almost always is a mosaic condition. The frequen
## Somatic chromosomal mosaicism may present as isolated pigmentary abnormalities or multiple congenital anomalies with mental retardation. Pigmentary lesions are visually dramatic and are differentiated based on appearance when the underlying pathogenesis is not known. It is now clear that mosaicis