Clinical features of patients with antibodies directed against proliferating cell nuclear antigen

✍ Scribed by Marvin J. Fritzler; Gale A. Mccarty; J. Paul Ryan; T. Douglas Kinsella

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 473 KB
• Volume: 26
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780260204

✦ Synopsis

Abstract

The clinical and serologic features of 7 patients whose sera contained antibodies directed against proliferating cell nuclear antigen (anti‐PCNA) were studied. Five of the patients had systemic lupus erythematosus (SLE), 1 had idiopathic diffuse proliferative glomerulonephritis, and 1 had seronegative arthritis. In a study of various rheumatic diseases, anti‐PCNA was found in 2% of SLE sera but was not found in the sera of 100 rheumatoid arthritis patients, 20 mixed connective tissue disease patients, or 50 diffuse scleroderma patients. Patients with anti‐PCNA had no history of hemolytic anemia, leukopenia, thrombocytopenia, or pleuro‐pericarditis. Evidence that the production of anti‐PCNA antibodies is sensitive to corticosteroid therapy is also presented.