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Clinical features and neuroimaging of PARK7-linked parkinsonism

✍ Scribed by Marieke Dekker; Vincenzo Bonifati; John van Swieten; Nico Leenders; Robert-Jan Galjaard; Pieter Snijders; Marten Horstink; Peter Heutink; Ben Oostra; Cornelia van Duijn

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
145 KB
Volume
18
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We recently reported linkage to chromosome 1p36 (the PARK7‐locus) in a family with early‐onset parkinsonism. Linkage to this locus has since been confirmed in an independent data set. We describe clinical and neuroimaging features of the 4 patients in the original PARK7‐linked kindred. Age at onset of parkinsonism varied from 27 to 40 years. Clinical progression was slow, and response to dopaminergic therapy good. The clinical spectrum ranged from mild hypokinesia and rigidity, to severe parkinsonism with levodopa‐induced dyskinesias and motor fluctuation. Three of four patients with PARK7‐linked parkinsonism exhibited psychiatric disturbances. Structural neuroimaging was unremarkable, but functional imaging of the brain, carried out in 3 patients, showed significant evidence for a presynaptic dopamine deficit, and assessment of cerebral glucose metabolism, as carried out in 1 patient, showed possible cerebellar involvement. © 2003 Movement Disorder Society

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