Species differences in the pharmacokinet
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J. A. Scatina; H. B. Kimmel; V. Weinstein; S. M. Troy; S. F. Sisenwine; M. N. Ca
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Article
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1990
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John Wiley and Sons
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English
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## Abstract The pharmacokinetics of recainam, an antiโarrhythmic drug, were compared in mice, rats, rabbits, dogs, rhesus monkeys, and man, Bioavailability was virtually complete in monkeys and dogs, 67 per cent in man and 51 per cent in rats. Nonโlinear kinetics between the oral and i.v. dose in r