Cystic fibrosis (CF) is an autosomal recessive disease characterized by obstruction and chronic infections of the respiratory tract and pancreatic insufficiency. The gene was cloned in 1989 and the most frequent mutation was shown to be the delta F508 mutation. During PGD, embryos obtained in vitro
Clinical evaluation of preimplantation genetic diagnosis
β Scribed by Alan H. Handyside
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 108 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0197-3851
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Three cases of preimplantation genetic diagnosis (PGD) (two for sexing and one for aneuploidy screening) are presented. Embryo biopsy was performed at day 3 and diagnosis was established with fluorescent in situ hybridization (FISH). Embryos not used for replacement were cultured in sequential media