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Clinical evaluation of chemotherapy response predictors developed from breast cancer cell lines

✍ Scribed by Cornelia Liedtke; Jing Wang; Attila Tordai; William F. Symmans; Gabriel N. Hortobagyi; Ludwig Kiesel; Kenneth Hess; Keith A. Baggerly; Kevin R. Coombes; Lajos Pusztai

Book ID: 106378311
Publisher: Springer US
Year: 2009
Tongue: English
Weight: 272 KB
Volume: 121
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-009-0445-7

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## Abstract Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P‐glycoprotein, an efflux membrane pump coded by the __MDR1 (A