The main objective in alcoholism therapy is to achieve and maintain abstinence and to prevent relapse. Pharmacotherapy may be necessary in treating persons who are not helped by group or psychosocial support alone. Among the substances experimented with in the past few years, gamma-hydroxybutyric ac
Clinical efficacy of gamma-hydroxybutyric acid in treatment of opiate withdrawal
โ Scribed by Luigi Gallimberti; Fabrizio Schifano; Giovanni Forza; Lorella Miconi; S. Davide Ferrara
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 251 KB
- Volume
- 244
- Category
- Article
- ISSN
- 1433-8491
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๐ SIMILAR VOLUMES
Gamma-hydroxybutyric acid (GHB) has been in clinical use in Italy since 1991 for treatment of alcohol dependence. Results of phase III and phase IV studies have shown that the drug is effective and well tolerated in the treatment of alcohol withdrawal syndrome and in reducing alcohol consumption and
Clonidine hydrochloride 5 micrograms/kg and placebo were given orally to 11 patients experiencing well-developed alcohol withdrawal states. Active drug and placebo were given in a randomised, cross-over double blind fashion 2 h apart. Clonidine significantly suppressed heart rate (P = 0.002), arteri