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Clinical efficacy of cerivastatin: phase IIa dose-ranging and dose-scheduling studies

✍ Scribed by Donald B Hunninghake


Book ID
113979778
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
143 KB
Volume
82
Category
Article
ISSN
0002-9149

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Trimetrexate (TMTX), a potent inhibitor of the enzyme dihydrofolate reductase, was shown to be more active than its analogue, Methotrexate, against murine and human tumor cell lines in vitro and in vivo. We conducted two sequential phase I studies using a single bolus injection of TMTX every 14 days