✍ Scribed by M. Filipová; M. Jung; V. Filip; H. Krejčová
No coin nor oath required. For personal study only.
The purpose of the study was to investigate whether 1-desamino-8-D-arginine-vasopressin (DDAVP) has a positive effect on mental performance in patients recovering from minor head injury. Seventeen inpatients with simple closed-head injury were included in the trial within 16-40 h after the accicent. DDAVP (Adiuretin SPOFA 10 pg b i d . or placebo were administered intranasally for 4 days under double-blind conditions. The test battery, consisting of several tests of memory and information processing, was administered at pretreatment and at the end of the trial. All patients completed the protocol, nine in the DDAVP group and eight in the placebo group. No adverse reactions to treatment were observed. In the first and second series of PASAT (an information processing test) and in the Story Memory (a test of verbal logical memory) DDAVP was significantly @<0.05) superior to placebo according to t-tests and/or ANCOVA with age as covariate. The results indicate a positive influence of DDAVP on information processing and short-term verbal logical memory during recovery from minor head injury.
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