Clinical effect of vitamin D3 analogues is not inactivated by subsequent UV exposure

Expression of common chromosomal fragile

Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR

✍ Elangovan Thavathiru; John H. Ludes-Meyers; Michael C. MacLeod; C. Marcelo Aldaz 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB

Common chromosomal fragile sites are unstable genomic loci susceptible to breakage, rearrangement, and are highly recombinogenic. Frequent alterations at these loci in tumor cells led to the hypothesis that they may contribute to cancer development. The two most common chromosomal fragile sites FRA1