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Clinical Correlations of Osteoarthritis Associated with a Single-Base Mutation (Arginine519 to Cysteine) in Type II Procollagen Gene

✍ Scribed by Yvonne L. Pun; Roland W. Moskowitz; Sutek Lie; Walter R. Sundstrom; Sidney R. Block; Currier Mcewen; H. James Williams; Jane F. Bleasel; Daniel Holderbaum; Tariq M. Haqqi

Book ID: 102754324
Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 588 KB
Volume: 37
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780370216

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. To investigate the occurrence and clinical correlation of the arg519-to-cys mutation in the type 11 procollagen gene in patients with osteoarthritis (OA).

Methods. Sixty-six subjects from 7 families with a strong family history of generalized OA and 13 patients with erosive OA were evaluated clinically and radiologically. Blood samples from 58 subjects in the familial OA

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