## BACKGROUND. Breast carcinoma commonly metastasizes to the skeleton in patients with advanced disease to cause bone destruction and the associated pain, hypercalcemia, fracture, and nerve-compression syndromes. In this scenario, the bone destruction is mediated by the osteoclast. Tumor-produced
Clinical consequences of osteolytic bone metastases
β Scribed by Namer, M.
- Book ID
- 123550611
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 106 KB
- Volume
- 12
- Category
- Article
- ISSN
- 8756-3282
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Osteolytic and osteoblastic metastases are often the cause of considerable morbidity in patients with advanced prostate and breast carcinoma. Breast carcinoma metastasis to bone occurs because bone provides a favorable site for aggressive behavior of metastatic cancer cells. A vicious cycle arises b
## Abstract Advanced prostate cancer is frequently accompanied by the development of metastasis to bone. In the past, prostate cancer bone metastases were characterized as being osteoblastic (i.e., increasing bone density) based on radiographs. However, emerging evidence suggests that development o