Clinical classification of hepatoma in Japan according to serial changes in serum alpha-fetoprotein levels
✍ Scribed by Yoshiro Matsumoto; Takashi Suzuki; Isam Asada; Kazue Ozawa; Takayoshi Tobe; Ichio Honjo
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 513 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
Quantitative determinations of serum alpha-fetoprotein (AFP) in 96 patients with hepatomas have demonstrated three main groups based on changes in the serial levels: 1) patients with more than 10 000 ng/ml during most of their clinical course, and with an increase of 10 000 ng/ml or more in a week (Group A); 2) patients with levels varying from 200 to 10 000 ng/ml and with an increase of 1000 ng/ ml in three to four months (Group B); and 3) patients with serum AFP levels below 200 ng/ml during most of their clinical course (Group C). The patients in Group A had a mean survival time of 7.62 ? 3.97 months, and those in Group B, 16.18 f 12.18 months. The patients in Group C were subdivided into two groups according to whether survival time was long (33.92 k 28.22 months) or short (3.75 f 0.87 months). Histologic findings revealed poorly differentiated carcinoma in patients in Group A, moderately differentiated carcinoma in those in Group B, and well differentiated carcinoma in those with long survival in Group C and anaplastic carcinoma in those with short survival in Group C.
Cancer 49354-360, 1982.
INCE Abelev' reported that alpha-fetoprotein ( AFP)