Clinical characteristics of small functioning adrenocortical tumors in children

✍ Scribed by Michalkiewicz, Edson L.; Sandrini, Romolo; Bugg, Michael F.; Cristofani, Lilian; Caran, Eliane; Cardoso, Ana Maria S.; Lacerda, Luiz de; Ribeiro, Raul C.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 49 KB
• Volume: 28
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199703)28:3<175::aid-mpo3>3.0.co;2-g

✦ Synopsis

Twenty of 67 children registered on the Inter-samples were histologically reviewed in 18 national Registry of Childhood Adrenocortical cases. Eight were adenomas, and 10 were carci-Tumors between May 1988 and December 1994 nomas (6 low grade and 4 high grade). Pathology had small adrenocortical tumors (defined for this records described tumor with diagnostic feastudy as measuring р 200 cm 3 and/or weighing tures of adrenocortical carcinoma in two paр 100 g). We reviewed the records of these 20 tients. One patient received mitotane for 8 patients to characterize the clinical and patho-months after surgery. Only one patient had relogic findings and outcomes of children with current disease, which was detected 6 months small adrenocortical tumors. Median patient after diagnosis and proved rapidly fatal. Another age was 2 years (range, 4 months to 5 years).

has been lost to follow-up. The remaining 18 There was only one boy. All had clinical signs patients are alive with no evidence of disease of virilization, and seven had signs or symptoms at a median 2.3 years (range, 6 months to 6.1 of Cushing syndrome. A median 5.5 months years) after diagnosis. Our data suggest that chil-(range, 1-40 months) had elapsed between the dren with small adrenocortical tumors have first signs of endocrine dysfunction and diagno-an excellent prognosis with surgery as the sole sis. All tumors were surgically resected. Tumor therapy, regardless of tumor histiotype. Med. volume was 3.3-195 cm 3 (median, 38.7 cm 3 ), Pediatr. Oncol. 28:175-178. and weight was 3.7-100 g (median, 36 g). Tumor